Individualized medicine and the microbiome in reproductive tract

Individualized medicine and the microbiome in reproductive tract

Humans have evolved along with the millions of microorganisms that populate their bodies. These microbes (10(14)) outnumber human cells by 10 to 1 and account for 3 × 10(6) genes, more than ten times the 25,000 human genes. This microbial metagenome acts as our "other genome" and like our own genes, is unique to the individual. Recent international efforts such as the Human Microbiome Project (...

Sperm Transport in the Mare Reproductive Tract: A Review

The objective of this study was to review the literature on sperm transport in the mare. During this process the sperm cells must reach the oviducts in order to fertilize the oocyte, but before reaching this site it must go through the uterus that is a hostile environment at this moment since there is an inflammatory reaction in this location that aims to eliminate excess spermatozoa and bacter...

The microbiome in respiratory medicine

Genetic variation and individualized medicine.

Mansell is with the Health, Physical Education, and Recreation Dept, Lincoln University, Lincoln University, PA. Tierney is with the Dept of Kinesiology, and Krynetskiy and Mishra, the School of Pharmacy, Temple University, Philadelphia, PA. Driban is with the Division of Rheumatology, Tufts Medical Center, Boston, MA. Clegg is with the Dept of Athletics, George Washington University, Washingto...

Pharmacogenetics, pharmacogenomics, and individualized medicine.

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...